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目的研究对氧磷酶1(PON1)基因R192Q位点、对氧磷酶2(PON2)基因C311S位点多态性与子痫前期(PE)发病的关系。方法应用聚合酶链反应(PCR)、限制性片段长度多态性(RFLP)方法分析PE组(73例)和健康孕妇组(66例)PON1基因多态性。结果 PE组和健康孕妇组PON1的基因型变异频率和R、Q等位基因频率差异均有统计学意义;PON2基因型变异频率和C、S等位基因频率差异亦有统计学意义。结论 PON1 R192Q位点多态性与PE发病有关,R等位基因可能是易感基因;PON2 C311S位点多态性与PE发病有关,C等位基因可能是易感基因。
Objective To investigate the relationship between PON1 gene R192Q, PON2 gene C311S polymorphism and preeclampsia (PE). Methods Polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) were used to analyze the polymorphism of PON1 gene in PE group (73 cases) and healthy pregnant women group (66 cases). Results The frequency of PON1 genotypes and the frequencies of R and Q alleles were significantly different between PE group and healthy pregnant women. The frequencies of PON2 genotypes mutation and C, S allele frequencies were also statistically significant. Conclusion The polymorphism of PON1 R192Q is associated with the pathogenesis of PE, and the R allele may be a susceptibility gene. The PON2 C311S polymorphism is associated with the pathogenesis of PE, and the C allele may be a susceptibility gene.