目的:探讨术前化疗、放疗联合手术综合方案治疗口腔中晚期鳞癌的临床效果。方法:对经病理确诊的104例口腔中晚期鳞癌患者行术前化疗、放疗1周期,再行联合根治手术。并对患者术后局部复发率、远处转移率、生存率、生活质量、张口度及钛板排斥、感染、断裂等情况进行临床观察。结果:口腔中晚期鳞癌术前化疗、放疗总有效率达98.08%,手术切除率达100%,术后不良反应轻,局部复发率1.92%(2例),远处转移率2.88%(3例),出现钛板排斥、感染反应导致张口受限2.88%(3例)。术后患者5年生存率91.35%(95例)。结论:术前化疗、放疗产生积极的抗肿瘤作用,取得满意的临床效果,为进一步手术治疗提供了良好的基础。术前化疗、放疗联合手术综合方案治疗中晚期口腔鳞癌,可提高患者远期生存率,手术切除率,术后不良反应轻。 Objective: To investigate the clinical effect of preoperative chemotherapy and radiotherapy combined with surgical treatment of advanced oral squamous cell carcinoma. Methods: 104 patients with pathologically diagnosed oral squamous cell carcinoma of the mouth underwent preoperative chemotherapy and radiotherapy for 1 cycle, followed by radical surgery. The clinical observation was made on the local recurrence rate, distant metastasis rate, survival rate, quality of life, mouth opening degree and titanium plate rejection, infection and fracture. Results: The total effective rate of preoperative chemotherapy and radiotherapy in advanced oral squamous cell carcinoma was 98.08%, the surgical resection rate was 100%, the postoperative adverse reactions were mild, the local recurrence rate was 1.92% (2 cases), the distant metastasis rate was 2.88% (3) Cases), there titanium plate rejection, infection caused by mouth restriction 2.88% (3 cases). The 5-year survival rate of postoperative patients was 91.35% (95 cases). Conclusion: Preoperative chemotherapy and radiotherapy have a positive anti-tumor effect and satisfactory clinical results, which provide a good foundation for further surgical treatment. Preoperative chemotherapy, radiotherapy combined with comprehensive surgical treatment of advanced oral squamous cell carcinoma, can improve long-term survival, surgical resection rate, postoperative adverse reactions were mild.