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目的:研究我院药物不良反应(ADR)发生特点及规律,为临床安全用药提供参考,为深入开展ADR监测工作提供依据。方法:收集我院2006年6月-2008年6月上报的770例ADR报告,分别从患者性别、年龄、给药途径、涉及药物种类以及ADR临床具体表现等方面进行统计并分析。结果:770例ADR报告中60岁以上老年患者较多,占29.62%;由抗菌药物导致的ADR最多,占42.55%;以静脉滴注方式为主,占79.24%;涉及系统以皮肤及附件损伤最为常见,占34.13%。结论:临床应重视ADR报告和监测工作,合理使用抗菌药物,以减少ADR发生。
Objective: To study the characteristics and rules of adverse drug reaction (ADR) in our hospital and to provide references for the clinical use of safe drugs, so as to provide the basis for further monitoring of ADR. Methods: A total of 770 cases of ADR reported in our hospital from June 2006 to June 2008 were collected and analyzed from the aspects of patient’s sex, age, route of administration, type of drug involved and the clinical manifestations of ADR. Results: The 770 ADR cases reported more elderly patients over the age of 60, accounting for 29.62%. The most ADR was caused by antibacterial drugs, accounting for 42.55%. The main method was intravenous infusion, accounting for 79.24%. The system involved skin and accessory injuries The most common, accounting for 34.13%. Conclusion: Clinical should pay attention to ADR reporting and monitoring, rational use of antimicrobial agents to reduce the occurrence of ADR.