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目的 :比较兔不同动脉对多巴胺 1(DA1)受体激动剂和多巴胺 2 (DA2 )受体激动剂舒张的效应 ,分析不同血管床多巴胺受体的生理特性。方法 :利用DA1受体激动剂FODA(Fenoldopam)和DA2 受体激动剂PBDA及其拮抗剂 ,测定离体血管环舒张反应的大小。结果 :①DA1受体激动剂FODA引起的舒张血管效应以肾、肠血管为最强 ,而肺血管较弱、股血管则基本无反应 ;②DA2 受体激动剂PBDA的舒血管效应则以股、肠动脉血管为最强 ,肾和肺血管仅有轻度反应 ;③FODA的舒血管效应除肺血管外 ,均无内皮依赖性 ;④用 6 羟多巴胺 (6 OHDA)处理的兔进一步证实在一些血管存在DA2 受体。结论 :尽管上述 4种血管床均存在有DA受体 ,但是不同血管多巴胺受体的亚型类别与反应特性存在有明显不同。
OBJECTIVE: To compare the effects of dopamine 1 (DA1) receptor agonist and dopamine 2 (DA2) receptor agonist on arterial relaxation in rabbits and to analyze the physiological characteristics of dopamine receptors in different vascular beds. Methods: The effects of DA1 receptor agonist FODA (Fenoldopam) and DA2 receptor agonist PBDA and its antagonist were measured. Results: ① The diastolic vasomotor effect induced by DA1 receptor agonist FODA was strongest in the kidney and intestine, while the pulmonary vessels were weak and the femoral vessels were almost non-responsive. ② The vasodilator effect of DA2 receptor agonist PBDA was in the femoral and intestine Arterial blood vessels were the strongest, and renal and pulmonary vessels only mild reaction; ③ vasodilator effect of FODA in addition to pulmonary vessels, no endothelium-dependent; ④ 6-hydroxydopamine (6 OHDA) rabbits further confirmed that in some blood vessels DA2 receptor. CONCLUSIONS: Although there are DA receptors in the above four vascular beds, the subtypes and response characteristics of different vascular dopamine receptors are significantly different.