CEA、CA199和CA724联合检查对结直肠癌的临床诊断价值

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目的:分析癌胚抗原(CEA)、糖类抗原199(CA199)和糖类抗原724(CA724)联合检查在结直肠癌(CRC)诊断中的临床价值。方法:选取东莞市中医院2016年1月至2016年12月确诊的结直肠癌患者50例为观察组对象,同期选择健康志愿者50例为对照组。两组均采用化学发光法对血清癌胚抗原(CEA)、糖类抗原199(CA199)、糖类抗原724(CA724)等进行检测。对比CEA、CA199和CA724联合检查与单项检查的区别。结果:观察组血清CEA、CA199、CA724等指标对照组相比均显著较高,且与单项检查相比,CEA、CA199和CA724联合检查的阳性率显著较高,差异具有统计学意义(P<0.05)。单项检查CEA、CA199、CA724的灵敏度分别为42.0%(21/50)、26.0%(13/50)、62.0%(31/50),联合检查CEA、CA199、CA724的灵敏度分别为96.0%(48/50),联合检查的灵敏度与单项检查相比均显著较高,差异具有统计学意义(P<0.05)。结论:CEA、CA199和CA724联合检查结直肠癌诊断的临床价值相对较高,即能提高患者临床确诊率,同时具有较高的灵敏度。 Objective: To analyze the clinical value of CEA, CA199 and CA724 in the diagnosis of colorectal cancer (CRC). Methods: Fifty patients with colorectal cancer confirmed by Dongguan Traditional Chinese Medicine Hospital from January 2016 to December 2016 were selected as observation group and 50 healthy volunteers were selected as control group. Chemiluminescence was used to detect serum carcinoembryonic antigen (CEA), carbohydrate antigen 199 (CA199) and carbohydrate antigen 724 (CA724) in both groups. Comparing the difference between CEA, CA199 and CA724 joint examination and single examination. Results: The serum CEA, CA199 and CA724 in the observation group were significantly higher than those in the control group, and the positive rates of CEA, CA199 and CA724 in the observation group were significantly higher than those in the single examination group (P < 0.05). The sensitivities of CEA, CA199 and CA724 were 42.0% (21/50), 26.0% (13/50) and 62.0% (31/50), respectively. The sensitivities of CEA, CA199 and CA724 were 96.0% (48) / 50). The sensitivity of combined examination was significantly higher than that of single examination, the difference was statistically significant (P <0.05). Conclusion: The clinical value of CEA, CA199 and CA724 combined examination of colorectal cancer diagnosis is relatively high, which can improve the clinical diagnosis of patients with high sensitivity.
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