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在 ０．１ｍｏｌ／Ｌ ＮａＨＣＯ_３介质中，用极谱法研究了 Ｏ_２~（·－）与黄体酮（ＰＲＧ）的化学反应．实验表明，与具有类似结构的糖皮质类甾体抑制磷脂酶 Ａ_２的活性从而间接阻 Ｏ_２~（·－）产生的机理不同，黄体酮与Ｏ_２~（·－）自由基的化学反应机制为叶氧化黄体酮分子中的烯酮基，Ｏ_２~（·－）自身被还原生成Ｈ_２Ｏ_２，ＰＲＧ是Ｏ_２~（·－）的清除剂．推导了化学反应速率常数公式，测得Ｏ_２~（·－）氧化黄体酮的表观化学反应速率常数为３０８ Ｌ·ｍｏｌ~（－１）·ｓ~（－１）．
The chemical reaction of O_2 ~ (-) with progesterone (PRG) was investigated by polarography in 0.1 mol / L NaHCO 3 medium. Experiments show that with a similar structure of the glucocorticoid steroid phospholipase A 2 activity and thus indirectly O 2 - (-) the mechanism of different progesterone and O 2 - (-) chemical reaction mechanism of the leaves Oxidation of progesterone in progesterone molecules, O_2 ~ (-) itself is reduced to H_2O_2, PRG is O_2 ~ (· -) scavenger. The formula of rate constant of chemical reaction was deduced. The apparent rate constant of O_2 - (-) oxidized progesterone was 308 L · mol -1 (-1) s -1.