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目的观察硫酸镁对新生儿缺氧缺血性脑损伤(HIBD)是否有保护作用。方法对93例新生儿HIBD随机分为硫酸镁治疗组和对照组,于生后7、14天进行行为神经测定评价,并评估心、肾、肺功能损害情况。结果治疗组较对照组神经功能明显改善,且重要脏器功能损害发生率减少。结论硫酸镁对HIBD神经损伤具有显著的保护作用,值得临床推荐。
Objective To observe whether magnesium sulfate has a protective effect on neonatal hypoxic-ischemic brain damage (HIBD). Methods Ninety-three neonates with HIBD were randomly divided into two groups: magnesium sulfate treatment group and control group. The neurobehavioral assessment was performed on the 7th and 14th days after birth, and the cardiac, renal and pulmonary dysfunction were evaluated. Results Compared with the control group, the neurological function of the treatment group was significantly improved, and the incidence of functional impairment of important organs decreased. Conclusion Magnesium sulfate has a significant protective effect on nerve injury caused by HIBD and is worthy of clinical recommendation.