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目的分析人表皮生长因子受体Her-3与Her-2在胃癌中表达的相关性及与胃癌生物学行为的关系。方法采用免疫组织化学(SP)法对我院100例进行胃癌手术的广东群体患者的胃癌组织中的Her-3与Her-2进行检测,并分析二者表达的相关性及其与胃癌患者的临床病理特征之间关系。结果胃癌组织中HER-2和HER-3高表达率分别为9%和21%;HER-3高表达与胃癌细胞的浸润深度、TNM分期、淋巴结转移相关(P<0.05);HER-2和HER-3高表达多见于贲门部(P<0.05);HER-2和HER-3协同表达与预后相关(P<0.05);HER-3高表达是胃癌独立的预后因素(P<0.01)。结论胃癌中Her-3与Her-2高表达比较常见,HER-2表达或HER-2和HER-3共表达均无预后意义,而Her-3表达可为胃癌的评估及预后判断提供指导依据。
Objective To analyze the relationship between the expression of human epidermal growth factor receptor Her-3 and Her-2 in gastric cancer and its relationship with the biological behavior of gastric cancer. Methods Her-3 and Her-2 were detected by immunohistochemistry (SP) in gastric cancer tissues of 100 patients with gastric cancer in our hospital. The correlations between the expression of Her-3 and Her-2 in gastric cancer were analyzed. Clinicopathological characteristics of the relationship between. Results The high expression rates of HER-2 and HER-3 in gastric cancer tissues were 9% and 21% respectively. The high expression of HER-3 was correlated with the depth of invasion, TNM stage and lymph node metastasis (P <0.05) The high expression of HER-3 was found in cardia (P <0.05). The synergistic expression of HER-2 and HER-3 was correlated with prognosis (P <0.05). The high expression of HER-3 was an independent predictor of gastric cancer (P <0.01). Conclusion Her-3 and Her-2 overexpression are common in gastric cancer. HER-2 expression or co-expression of HER-2 and HER-3 have no prognostic significance in gastric cancer, and Her-3 expression may provide a guideline for the assessment and prognosis of gastric cancer .