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目的:探讨生长抑制基因(inhibitor of growth,p33ING1)在结直肠癌中的表达意义,以及p33ING1与结直肠癌临床病理特征的关系及其可能的作用机制。方法:对60例结直肠癌组织及20例癌旁非肿瘤组织标本,应用免疫组化检测肿瘤组织和正常组织的p33ING1、p21WAF1的表达。结果:p33ING1在结直肠癌组织中的表达阳性率为43.3%,在正常组织中为90.0%,显著低于正常组织(P<0.005);p33ING1减低与结直肠癌的Dukes分期及淋巴结转移有一定关系(P<0.005和P<0.01),而与患者的性别、年龄、肿瘤分化程度、肿瘤部位及浸润深度无明显关系(P>0.05)。p33ING1与p21WAF1表达呈正相关关系(P<0.05)。结论:p33ING1在结直肠癌组织中低表达,对结直肠癌的发生、发展可能起着重要的作用;p33ING1、p21WAF1表达可作为判断结直肠癌恶性程度的重要指标之一。
Objective: To investigate the expression of p33ING1 in colorectal cancer and the relationship between p33ING1 and clinicopathological features of colorectal cancer and its possible mechanism. Methods: The expression of p33ING1 and p21WAF1 in tumor tissues and normal tissues were detected by immunohistochemistry in 60 cases of colorectal cancer tissues and 20 cases of adjacent non-tumor tissues. Results: The positive rate of p33ING1 was 43.3% in colorectal cancer tissues, 90.0% in normal tissues and significantly lower than that in normal tissues (P <0.005). The decrease of p33ING1 was associated with Dukes stage and lymph node metastasis of colorectal cancer (P <0.005 and P <0.01), but not with the gender, age, tumor differentiation, tumor location and depth of invasion (P> 0.05). There was a positive correlation between p33ING1 and p21WAF1 expression (P <0.05). CONCLUSION: The low expression of p33ING1 in colorectal cancer tissues may play an important role in the development of colorectal cancer. The expression of p33ING1 and p21WAF1 may be one of the important indicators for evaluating the malignant degree of colorectal cancer.