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肿瘤微循环对肿瘤生长和转移至关重要.冷热交替治疗已被证实优于以往的单一冷疗或热疗,其对于肿瘤微循环的损伤程度及机理是肿瘤成功治疗的关键,但目前该方向的研究甚少.利用裸鼠脊背皮翼肿瘤视窗模型结合激光共聚焦显微镜技术综合比较了单冷、单热及冷热交替对肿瘤微循环的损伤程度,并建立了分析肿瘤血管在热物理作用下受力的理论模型,通过数值计算获得了冷热交替治疗过程中肿瘤微循环血管壁的受力大小.研究结果发现,冷热交替造成了肿瘤微循环尤其是肿瘤中央成熟血管严重的结构性损伤.冷热交替过程中,血管壁先后受到迅速变化的方向相反的热应力,有可能在血管壁形成微小裂纹.随后加热造成的血流快速再灌注对血管壁的作用力存在应力集中现象,推测血液流动对肿瘤血管壁的快速冲击力很可能是造成血管壁破裂的关键因素,初步揭示了冷热交替治疗过程中肿瘤血管发生严重损伤的机理.
Tumor microcirculation is crucial for the growth and metastasis of tumor.It has been proved that hot and cold alternation therapy is better than single cold or hyperthermia in the past and the degree and mechanism of tumor microcirculation damage is the key to the successful treatment of tumor.However, The direction of the study is very little.Using the model of spinal dorsal toe tumor in nude mice combined with laser confocal microscopy to compare the single cold, single hot and cold alternating on the degree of tumor microcirculation damage, and the establishment of the analysis of tumor blood vessels in thermal physics Under the action of stress theoretical model, obtained by numerical calculation of alternating cold and hot tumor microcirculation vessel wall force size.The results showed that alternating cold and hot caused by the tumor microcirculation, especially in the central structure of the tumor mature blood vessels serious Sexual injury.At cold and heat alternating process, the vascular wall has been subjected to rapid changes in the direction of the opposite thermal stress, there may be micro-cracks in the blood vessel wall.Following the blood flow caused by rapid reperfusion on the vessel wall there is stress concentration phenomenon , Suggesting that the rapid impact of blood flow on the tumor vessel wall is likely to be the key factor causing rupture of the vessel wall, initially revealed Mechanism of tumor angiogenesis during alternating hot and cold treatment of severe injury.