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目的 :探讨鼠神经生长因子(m NGF)联合甲泼尼龙对格林-巴利综合征(GBS)炎症反应的影响。方法 :将2014年5月~2016年5月于我院治疗的58例GBS患者分为两组:对照组29例,单独应用甲泼尼龙进行治疗;观察组29例,在此基础上再联合使用m NGF;对比两组患者的血清、脑脊液(cerebrospinal fluid,CSF)炎症因子[白介素12(IL-12)、白介素21(IL-21)、白介素23(IL-23)]、CSF细胞学检查结果(蛋白细胞分离情况、细胞计数及细胞学异常情况)与临床疗效。结果 :观察组的临床疗效优于对照组,但差异无统计学意义;两组治疗后血清、CSF的IL-12、IL-21、IL-23水平与治疗前相比均明显下降,除CSF IL-21以外观察组下降更显著;CSF细胞学检查结果与治疗前相比也明显好转。结论 :m NGF联合甲泼尼龙治疗GBS能明显改善炎症反应情况。
Objective: To investigate the effects of m NGF combined with methylprednisolone on inflammatory response in Guillain-Barre Syndrome (GBS). Methods: Fifty-eight patients with GBS who were treated in our hospital from May 2014 to May 2016 were divided into two groups: control group (n = 29), methylprednisolone treatment alone (n = 29) and observation group (n = 29) The levels of inflammatory cytokines (interleukin 12 (IL-12), interleukin 21 (IL-21) and interleukin 23 (IL-23)) and CSF cytology were compared between the two groups. Results (protein cell isolation, cell count and cytology abnormalities) and clinical efficacy. Results: The clinical efficacy of the observation group was better than that of the control group, but the difference was not statistically significant. The levels of IL-12, IL-21 and IL-23 in the serum and CSF of the two groups were significantly lower than those before treatment IL-21 outside the observation group decreased more significantly; CSF cytology results also significantly improved compared with before treatment. Conclusion: The combination of m NGF and methylprednisolone can significantly improve the inflammatory response.