论文部分内容阅读
目的探讨甲状腺乳头状癌(PTC)中BRAFV600E突变与淋巴结转移之间的相关性。方法采用PCR直接测序法检测65例PTC患者肿瘤细胞DNA中BRAFV600E点突变,分析其与淋巴结转移的相关性。结果 BRAFV600E点突变在PTC中的发生率为61.5%(40/65),其中40例BRAFV600E突变的PTC中有14例淋巴结转移,而未突变的25例患者中有淋巴结转移者10例,BRAFV600E点突变与淋巴结转移无相关性(P=0.7932)。结论 BRAFV600E可能参与PTC的发生,但与PTC淋巴结转移无相关性。
Objective To investigate the correlation between BRAFV600E mutation and lymph node metastasis in papillary thyroid carcinoma (PTC). Methods The DNA of BRAFV600E in 65 patients with PTC was detected by PCR direct sequencing. The correlation between BRAFV600E mutation and lymph node metastasis was analyzed. Results The incidence of BRAFV600E point mutation in PTC was 61.5% (40/65). Of the 40 BRAFV600E mutation PTCs, 14 had lymph node metastases, while in the non-mutated 25 patients, 10 had BRAFV600E There was no correlation between mutation and lymph node metastasis (P = 0.7932). Conclusion BRAFV600E may be involved in the occurrence of PTC, but not with PTC lymph node metastasis.