论文部分内容阅读
Objective This study aimed to investigate the dose calculation accuracy of individualized bulk electron density ( IBED) assignment approaches for simulated magnetic resonance imaging ( MRI)-only planning of thoracic tumors via the use of a 3DVH system. Methods 8 patients with thoracic cancer were included in this study. Based on standard planning CT,single-arc dynamic conformal therapy ( DCT) and double-arc volumetric modulated arc therapy ( VMAT) plans with a 6 MV photon beam were generated as a baseline plan ( Plan-CT) for each patient. The simulated MRI-only planning ( Plan-IBED) was implemented by copying the Plan-CT and forcing the electron density of each region of interest to its av-erage value and recalculating the dose distribution. A 3DVH system was used to visualize and compare the dosimetric differ-ences between Plan-CT and Plan-IBED,and the criteria of the 3D-Gamma pass rate were set to 1. 0%/1. 0 mm. Results The maximum percentage relative deviation ( MPRD) of the dosimetric parameters D2 ,D95 ,D98 ,and Dmean of planning tumor volumes (PTVs) between Plan-CT and Plan-IBED was less than 1. 3%. The MPRD of the average dose for organs at risk (OARs) was less than 1. 5%. The MPRDs of the lung V5,V20,and V30 were 1. 29%,3. 26%,and 2. 78%,respectively. Gamma analysis revealed an averaged pass rate of>95. 0% for the body,as well as between 91. 9% and 98. 2% for OARs. Conclusion The proposed IBED assignment in simulated MRI-only treatment planning allows for dose calculation with com-parable accuracy to the baseline plan and is appropriate for thoracic tumors.