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The changes of lysosomes of the hepatocytes in 27 rats aged 1,5,15,30,50 and 90 days respectively were observed with morphometry andby studying the ultrastructures.The results indicate that during thisperiod of development,the volume density and the numerical density ofthe lysosomes markedly increased.Lysosomes originally scattered inthe cytoplasm of the hepatocytes gradually migrated to the peripheryof the bile canaliculi,and the changes of the proportions amongcertain forms of secondary lysosomes were also observed.The author,considering from all the results,suggest that the first 5 days of the lifeof the rats is a critical period for the development of the lysosomesof the hepatocytes.
The changes of lysosomes of the hepatocytes in 27 rats aged 1,5,15,30,50 and 90 days respectively were observed with morphometry andby studying the ultrastructures.The results indicate thisperiod of development, the volume density and the numerical density ofthe lysosomes markedly increased inthe cytoplasm of the hepatocytes gradually migrated to the peripheryof the bile canaliculi, and the changes of the proportions amongcertain forms of secondary lysosomes were also observed.The author, considering from all the results, suggest that the first 5 days of the life of the rats is a critical period for the development of the lysosomes of the hepatocytes.