【摘 要】
：
Dear Editor,Lassa virus (LASV) belongs to the Mammarenavirus genus,Arenaviridae family.Arenaviruses are classified into two main groups—Old World (OW) and New
【机 构】
：
State Key Laboratory of Virology, Wuhan Institute of Virology,Chinese Academy of Sciences, Wuhan 430
论文部分内容阅读
Dear Editor,Lassa virus (LASV) belongs to the Mammarenavirus genus,Arenaviridae family.Arenaviruses are classified into two main groups—Old World (OW) and New World (NW)—based on virus genetics,serology,antigenic properties and geographical relationships.The OW LASV and Lujo virus (LUJV),as well as NW Junín virus (JUNV),Machupo virus (MACV),Guanarito virus (GTOV),Sabiá virus (SABV) and Chapare virus (CHAPV),are known to cause severe hemorrhagic fever and are listed as biosafety level 4 (BSL-4)agents.The arenavirus glycoprotein complex (GPC) contains three subunits—the retained stable-signal peptide (SSP),the receptor-binding subunit GP1,and the membrane fusion subunit GP2 (Lenz et al.,2001).Notably,the proximate exteal membrane region and TM of GP2,together with the ectodomain loop and TMs of SSP,form an SSP-GP2 interface,playing essential roles in regulating membrane fusion,and providing targets for distinct fusion inhibitors (Larson et al.,2008;Lee et al.,2008;York et al.,2008;York and Nunberg,2009;Thomas et al.,2011;Burgeson et al.,2013a;Shankar et al.,2016;Wang et al.,2016;Wang et al.,2018).
其他文献
Dear Editor,Lipid droplets (LDs) are dynamic lipid-storage organelles of storage depots and sources of essential substrates for myriad cellular processes and pr
Dear Editor,Propofol (2,6-diisopropylphenol) has been widely used in clinical surgery because of its fast induction and rapid recovery effects (Miller et al.,20
Dear Editor,Type Ⅰ interferons (IFNs) are secreted in the context of viral infection and mediate the expression of more than 300 IFN-stimulated genes (Schoggin
Dear Editor,L-Fucose (6-deoxy-L-galactose,fucose) is the basic component of a variety of glycan structures.The fucosylated oligosaccharides participate in a var
Dear Editor,Current research has demonstrated that the dynamic distribution of histone variant H2A.Z at specific loci can be regulated by ATP-dependent chromati
Dear Editor,Newly engineered tissues often fail to function due to insufficient blood vessels formation.Autologous vascular endothelial cells are ideal sources
Dear Editor,The clustered regularly interspaced short palindromic repeats (CRISPR)-associated (Cas) system is an adaptive immune system in a variety of bacteria
With great interest we have read the study of Liu et al.(2018) revealing the role of RNA binding protein 24 (RBM24) on global alteative splicing and dilated car
Dear Editor,Herpesviridae is a large family of double-stranded DNA (dsDNA) viruses that cause a variety of human diseases ranging from cold sores and chicken po