体外胸腺细胞分化为CTL需要抗原或促有丝分裂原的刺激.此外据报道IL-2,IL-4,IL-5,IL-6,IL-10,TNF及IFN-γ)也在此过程中起作用.CTL前体细胞(CTL-P)是不是某一IL的唯一靶细胞;是否不同亚群的T细胞先受刺激产生第二种介质依次最终导致CTL的分化,这些问题一直存在.为此,研究了IL-6诱导的ConA刺激后CD4~-CD8~+CTL-P分化的形式.结果发现,在去除了辅助细胞的胸腺细胞发育过程中,①rIL-1和rIL-6均可诱 In vitro thymocytes differentiate into CTLs that require antigens or mitogenic stimuli.In addition, it has been reported that IL-2, IL-4, IL-5, IL-6, IL-10, TNF and IFN- The role of CTL precursors (CTL-P) is not the only target cell of a particular IL; these problems persist despite the fact that T cells of different subpopulations are stimulated to produce a secondary mediator which in turn eventually leads to CTL differentiation , The form of CD4 ~ -CD8 ~ + CTL-P differentiation after IL-6-induced ConA stimulation was studied.It was found that both rIL-1 and rIL-6 were induced during thymocyte development without helper cells