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目的分析研究甲状腺肿患者尿液及血清中碘、双酚A(BPA)水平与正常者之间的差异,以期为甲状腺肿的预防提供新的思路。方法 62例甲状腺肿患者作为甲状腺肿组,另选取同期在本院体检健康者62例作为正常组,对其血清及尿液进行检测,对比两组研究对象尿碘、尿BPA及血清碘和BPA水平。结果甲状腺肿组尿碘、尿碘/肌酐水平均明显高于正常组,差异有统计学意义(P<0.05);甲状腺肿组尿BPA、尿BPA/肌酐水平均明显高于正常组,差异有统计学意义(P<0.05);甲状腺肿组血清碘和BPA水平与正常组比较差异无统计学意义(P>0.05)。结论高尿碘状态、高尿BPA水平与甲状腺肿发病密切相关,并且尿液中的BPA和碘之间呈正相关。
Objective To analyze the difference between the levels of iodine and bisphenol A (BPA) in the urine and serum of goiter patients, and to provide a new idea for the prevention of goiter. Methods Sixty-two patients with goiter were selected as goiter. Sixty-two healthy people in our hospital were selected as the normal group during the same period. Serum and urine were detected. Urine iodine, urine BPA and serum iodine and BPA were compared between the two groups Level. Results The levels of urinary iodine and urinary iodine / creatinine in goiter group were significantly higher than those in normal control group (P <0.05). The levels of urinary BPA and urinary BPA / creatinine in goiter group were significantly higher than those in normal control group Statistical significance (P <0.05); The serum iodine and BPA levels in goiter group had no significant difference compared with normal group (P> 0.05). Conclusion High urinary iodine status and high urinary BPA levels are closely related to the incidence of goiter, and there is a positive correlation between urine BPA and iodine.