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目的 :观察急性胰腺炎患者血浆肾素和血管紧张素Ⅱ的动态变化。方法 :自 2 0 0 1年 9月～ 2 0 0 3年 12月在我院住院治疗的患者中选择 2 3例急性胰腺炎患者作为观察对象 ,并选择同期住院的消化性溃疡患者 2 1例作为对照组 ,两组患者分别在入院的第 1天 ,第 7天 ,第 14天和第 2 1天时采血检验血浆肾素和血管紧张素Ⅱ的水平并进行比较。结果 :急性胰腺炎患者在病程早期血浆肾素活性和血管紧张素Ⅱ的水平有明显增高 ,而在病程的第 3周和第 4周则有明显降低。消化性溃疡组患者在病程不同时期肾素活性和血管紧张素Ⅱ的水平没有明显变化 ,并且都明显低于急性胰腺炎组患者。结论 :肾素 -血管紧张素系统激活及活性产物的大量产生与急性胰腺炎的病程发展有关系密切。
Objective: To observe the dynamic changes of plasma renin and angiotensin Ⅱ in patients with acute pancreatitis. METHODS: Twenty-three patients with acute pancreatitis from September 2001 to December 2003 in our hospital were enrolled in this study. Twenty-one patients with peptic ulcer were enrolled in this study. As a control group, plasma levels of rennin and angiotensin II were measured in the two groups on the first day, the seventh day, the fourteenth day and the 21st day on admission, and compared. Results: The plasma renin activity and the level of angiotensin Ⅱ were significantly increased in patients with acute pancreatitis at the early stage of the course of disease, but significantly decreased at the third and fourth week of the course. Peptic ulcer patients at different stages of the course of renin activity and the level of angiotensin II did not change significantly, and were significantly lower than the group of patients with acute pancreatitis. CONCLUSION: The activation of renin-angiotensin system and the massive production of active product are closely related to the course of development of acute pancreatitis.