论文部分内容阅读
目的:探讨急性胰腺炎(AP)合并肝损害的临床特点及发病机制。方法:对两家医院自2000年1月至2009年11月所收治的176例AP进行回顾性临床分析。结果:176例AP中有128例合并肝损害(占72.72%),重型胰腺炎肝损害程度较轻型胰腺炎肝损害重,差异有显著性,P<0.05。结论:AP合并肝损害发病率较高,其程度与急性胰腺炎病情程度成正相关,其发病机制是炎性破坏因子,多种炎性介质,胆汁淤积,内毒素等多因素结果。因此AP并发肝损时首选积极治疗原发病,同时加强保肝治疗,保护肝脏功能是非常重要的。
Objective: To investigate the clinical features and pathogenesis of acute pancreatitis (AP) combined with liver damage. Methods: A retrospective clinical analysis of 176 AP patients admitted to the two hospitals from January 2000 to November 2009 was performed. Results: 128 of 176 patients had hepatic injury (72.72%), and severe hepatic injury of severe pancreatitis was more severe than that of mild pancreatitis (P <0.05). Conclusion: The incidence of AP complicated with liver damage is high, and the degree of AP is positively correlated with the severity of acute pancreatitis. The pathogenesis of AP is associated with inflammatory factors, inflammatory mediators, cholestasis and endotoxin. Therefore, the first choice for AP complicated with active liver disease treatment of primary disease, while strengthening liver protection, liver function is very important.