急性淋巴细胞白血病(ALL)是常见的白血病之一,好发于儿童,在成人急性白血病中占15%~20%。随着化疗方法的不断改进,儿童缓解率达90%以上,成人ALL已有75%~89%可获得完全缓解(CR),但缓解后成人ALL复发率较高,临床病死率高。难治复发性ALL目前仍是血液科临床 Acute lymphoblastic leukemia (ALL) is one of the common leukemias, occurs in children, accounting for 15% to 20% of adult acute leukemia. With the continuous improvement of chemotherapy, the remission rate of children is over 90%. Complete remission (CR) is achieved in 75% ~ 89% of adult ALL patients. However, the remission rate of adult ALL patients is high, and the clinical mortality rate is high. Refractory recurrent ALL is still clinically hematological