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胰腺癌为一种常见病,但伴有神经内分泌类型的胰腺癌实属罕见,近几年来,我们利用免疫组化技术对胰腺癌进行了对比观察,从中发现其4例.现报导如下:1 病案报告例1 患者男,62岁.上腹痛2月,出现黄疸20余天而于1995年4月入院.B超及CT检查均提示胰腺占位性病变.手术中见胰头部有一10cm×8cm×8cm肿瘤,与周围组织紧密粘连无法切除.取1.5cm×1cm×1cm组织做病理检查,瘤组织呈灰白灰黄色,质地较硬,镜检示瘤细胞大小较一致,核有异型,分裂像易见,胞浆较丰富,瘤组织呈腺样结构.免疫组化检查:ABC方法,DAKO公司进口试剂,S_(100)阳性、NSE阳性、CEA阳性、Serotonin阳性、Chromogranin-A阳性.病理诊为神经内分泌型胰腺癌.例2 患者女,53岁.上腹痛3月余,有时恶心、呕吐、无黄疸.B超检查示胰腺肿瘤.术中见胰尾部有一3cm×3cm×
Pancreatic cancer is a common disease, but pancreatic cancer with neuroendocrine types is rare. In recent years, we have used immunohistochemical techniques to observe the pancreatic cancer and found 4 cases of it. The report is as follows: 1 Case Report Patient 1 Male, 62 years old. Abdominal pain 2 months, there were more than 20 days of jaundice and was admitted to hospital in April 1995. B-ultrasonography and CT examinations all suggest pancreatic space-occupying lesions. See pancreatic head with a 10cm × 8cm during the operation ×8cm tumor, with close adhesion with the surrounding tissue can not be removed. Take 1.5cm × 1cm × 1cm tissue for pathological examination, tumor tissue was grayish gray and yellow, hard texture, microscopic examination showed that the tumor cell size is more uniform, nuclear heterogeneous, split like Easy to see, abundant cytoplasm, tumor tissue showed adenoid structure. Immunohistochemical examination: ABC method, DAKO company imported reagents, S_ (100) positive, NSE positive, CEA positive, Serotonin positive, Chromogranin-A positive. Pathological diagnosis Neuroendocrine pancreatic cancer. Case 2 Female patient, 53 years old. Abdominal pain more than 3 months, sometimes nausea, vomiting, no jaundice. B-ultrasonic examination showed pancreatic tumor. See the pancreatic tail has a 3cm × 3cm × ×