非甾体抗炎药是临床常用的一类药物,有良好的抗炎、镇痛及解热作用,但与其他药物合用时,常可产生一些不良的相互作用,本文简述如下。 1.与抗酸药合用抗酸药可使体液及尿液pH升高,阿司匹林为弱酸性药物,在碱性条件下解离度增大,肾小管重吸收减少,排泄量增加,因而血药浓度降低(有时甚至降到有效血药浓度以下),疗效也降低,故必要时应调整阿司匹林用量。消炎病与抗酸药 Non-steroidal anti-inflammatory drugs are a class of commonly used drugs, have good anti-inflammatory, analgesic and antipyretic effect, but when combined with other drugs, often can produce some adverse interactions, this article is briefly described below. 1. Antacids combined with antacids can make the pH of body fluids and urine increased, aspirin is a weak acid drugs, increased dissociation in alkaline conditions, decreased tubular reabsorption, increased excretion, and thus blood medicine Lower concentration (and sometimes even below the effective plasma concentration), the curative effect is also reduced, so when necessary, adjust the amount of aspirin. Anti-inflammatory disease and antacids