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目的比较多索茶碱与氨茶碱治疗支气管哮喘疾病的临床疗效。方法回顾性收集支气管哮喘疾病患者88例,按照随机数字法分为研究组和对照组各44例。对照组采用氨茶碱治疗,研究组采用多索茶碱治疗,观察2组患者的临床疗效。治疗前后测定2组患者肺功能指标,包括PEF、FEV_1/FVC、FVC、FEV_1,痰嗜酸粒细胞比例、FeNO。结果研究组治疗总疗效90.91%高于对照组75.00%,差异有统计学意义(χ~2=7.9032,P<0.05)。2组肺功能指数(PEF、FEV_1/FVC、FVC、FEV_1)治疗前比较差异无统计学意义(P>0.05);治疗后研究组肺功能指数优于对照组,差异有统计学意义(P<0.05)。治疗后研究组Fe NO指数低于对照组,嗜酸粒细胞比例高于对照组,差异有统计学意义(P<0.05)。结论临床治疗支气管哮喘疾病可在常规治疗基础上给予多索茶碱药物,此药物和氨茶碱对比,其疗效更为突出,明显改善肺通气功能、Fe NO、嗜酸粒细胞比例等指数,安全性高,有较大应用性和推广性。
Objective To compare the clinical efficacy of doxofylline and aminophylline in the treatment of bronchial asthma. Methods A total of 88 patients with bronchial asthma were retrospectively collected. According to the random number method, they were divided into study group (44 cases) and control group (44 cases). The control group was treated with aminophylline, the study group was treated with doxofylline, and the clinical efficacy was observed in the two groups. Before and after treatment, pulmonary function parameters of two groups were measured, including PEF, FEV 1 / FVC, FVC, FEV 1, sputum eosinophil ratio and FeNO. Results The total efficacy of the study group was 90.91% higher than that of the control group 75.00%, the difference was statistically significant (χ ~ 2 = 7.9032, P <0.05). There was no significant difference in pulmonary function index (PEF, FEV 1 / FVC, FVC, FEV 1) between the two groups before treatment (P> 0.05). After treatment, the pulmonary function index of the study group was better than that of the control group (P < 0.05). After treatment, the Fe NO index of the study group was lower than that of the control group, and the percentage of eosinophils was higher than that of the control group (P <0.05). Conclusion The clinical treatment of bronchial asthma disease can be given on the basis of conventional treatment of doxofylline drugs, this drug compared with aminophylline, its efficacy is more prominent, significantly improved lung ventilation, Fe NO, eosinophil ratio and other indices, High security, greater applicability and promotion.