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目的：观察α-干扰素（IFN-α）对12例小儿乙型肝炎病毒相关性肾炎的治疗效果。方法：先给予强的松按lmg·kg－1·d－1治疗2周后突然停药，此时开始应用α-干扰素100万单位，隔天一次肌注，疗程共6个月。观察患儿血HBV抗原的转变，尿蛋白及血生化的变化。结果：10例HBeAg（＋）患儿中的4例转为（－），12例HBsAg（＋）患儿中的3例转为（－），5例尿蛋白转阴，3例明显好转，总有效率为66．7％（8／12）。病理类型为MN及MSPGN疗效较好，而对MPGN者则效果较差。结论：该剂量疗程的干扰素对小儿乙肝病毒相关性肾炎的治疗具有一定效果。
Objective: To observe the therapeutic effect of interferon-α (IFN-α) on 12 children with hepatitis B virus-associated nephritis. Methods: Prednisone was given by lmg · kg-1 · d-1 for 2 weeks and then stopped suddenly. At this time, 1 million interferon alpha units were used and intramuscular injection was given every other day for 6 months. Observe the changes of blood HBV antigen, urinary protein and blood biochemical changes in children. RESULTS: Of the 10 HBeAg (+) children, 4 (-) were converted to (-), 3 of 12 HBsAg (+) were converted to (-), 5 were negative for urinary protein, 3 were significantly improved, The total effective rate was 66.7% (8/12). Pathological types of MN and MSPGN better effect, while the MPGN were less effective. Conclusion: The dose of interferon treatment of children with hepatitis B virus-associated nephritis has some effect.