【摘 要】
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Rapid large-area tissue imaging at the cellular resolution is important for clinical diagnosis. We present a probe-based confocal microendoscope (pCM) with a field-of-view (FOV) diameter over 500 μm, lateral resolution of 1.95 μm, and outer diameter of 2.
【机 构】
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BrittonChanceCenterforBiomedicalPhotonics,WuhanNationalLaboratoryforOptoelectronics,HuazhongUniversi
【出 处】
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PhotonicsResearch
论文部分内容阅读
Rapid large-area tissue imaging at the cellular resolution is important for clinical diagnosis. We present a probe-based confocal microendoscope (pCM) with a field-of-view (FOV) diameter over 500 μm, lateral resolution of 1.95 μm, and outer diameter of 2.6 mm, compatible with the biopsy channel of conventional gastroscopes. Compared to a conventional pCM, our system’s FOV increased by a factor of 4 while maintaining the probe size and cellular resolution—comparable to the FOV of Zeiss Axio Observer’s numerical aperture objective lens. Ex vivo imaging of wide areas in healthy and diseased rat gastrointestinal tract tissues demonstrates the system’s practicality.
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