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目的探讨妇科恶性肿瘤患者采用紫杉醇脂质体治疗的效果及不良反应情况。方法 103例恶性肿瘤患者,随机分为研究组(52例)和对照组(51例)。研究组采用紫杉醇脂质体和异环磷酰胺进行联合治疗,对照组采用异环磷酰胺进行治疗。对比两组患者的临床效果、不良反应情况。结果研究组患者总有效率为71.2%,对照组为45.1%,研究组患者治疗效果显著优于对照组,差异具有统计学意义(χ~2=14.68,P<0.01);研究组患者在用药期间不良反应发生率为32.7%,对照组为52.9%,研究组明显少于对照组,差异具有统计学意义(χ~2=10.31,P<0.01)。结论采用紫杉醇脂质体治疗妇科恶性肿瘤可有效提高患者的治疗效果和生存率,减小不良反应,具有临床价值。
Objective To investigate the efficacy and adverse reactions of paclitaxel liposomes in patients with gynecologic malignancies. Methods 103 patients with malignant tumor were randomly divided into study group (52 cases) and control group (51 cases). The study group was treated with paclitaxel liposome and ifosfamide, while the control group was treated with ifosfamide. The clinical effects and adverse reactions of the two groups were compared. Results The total effective rate was 71.2% in the study group and 45.1% in the control group. The treatment effect in the study group was significantly better than that in the control group (χ ~ 2 = 14.68, P <0.01). In the study group, The incidence of adverse reactions was 32.7% in the control group and 52.9% in the control group, which was significantly lower in the study group than in the control group (χ ~ 2 = 10.31, P <0.01). Conclusion The use of paclitaxel liposomes in the treatment of gynecological malignancies can effectively improve the therapeutic effect and survival rate of patients, reduce the adverse reactions, and has clinical value.