目的：探讨肝外胆道动力学因素在胆囊结石形成中的作用。方法：选用家兔４７只随机分为４组。对照组（ｎ＝１３），成石组（ｎ＝１４），消炎痛组（ｎ＝１０），红霉素组（ｎ＝１０）。饲养４周后检测成石情况、胆总管压力等指标。结果：成石组１２／１４只形成结石，消炎痛组４／１０只形成结石，红霉素组无一只形成结石。成石组胆汁中胆固醇和粘蛋白含量显著增高，胆囊管阻力和胆总管压力显著增高，胆囊排空率显著降低。消炎痛组较成石组胆汁中粘蛋白浓度降低，胆囊管阻力下降，胆总管压力下降，胆囊排空率无显著改善。红霉素组较成石组胆汁粘蛋白含量下降，胆囊管阻力下降，胆囊排空率增加而胆总管压力无显著变化。结论：除胆汁成分异常外，肝外胆道动力学因素参与了胆囊结石形成，改变肝外胆道动力学因素以促进胆囊排空，能有效地防止胆囊结石形成 Objective: To investigate the role of extrahepatic biliary dynamics in gallstone formation. Methods: 47 rabbits were randomly divided into 4 groups. The control group (n = 13), Chengshi group (n = 14), indomethacin group (n = 10) and erythromycin group (n = 10). Feeding after 4 weeks into stone conditions, common bile duct pressure and other indicators. Results: Only 12/14 stones were formed in Chengshi Formation, 4/10 stones were formed in indomethacin group, and no stones were found in erythromycin group. Chengshi group bile cholesterol and mucin content was significantly increased, cystic duct resistance and common bile duct pressure was significantly increased, the gallbladder emptying rate was significantly reduced. Indomethacin group compared with Chengshi group bile mucin concentration decreased, cystic duct resistance decreased, common bile duct pressure decreased, the gallbladder emptying rate no significant improvement. In Erythromycin group, the content of bile mucin decreased, the cystic duct resistance decreased, the rate of gallbladder emptying increased and the common bile duct pressure had no significant change. Conclusion: In addition to the abnormal bile composition, extrahepatic biliary dynamic factors are involved in the formation of gallstones, changes in extrahepatic biliary dynamics to promote gallbladder emptying, can effectively prevent the formation of gallstones