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目的:评价大剂量醛氢叶酸(CF)、氟尿嘧啶(5Fu)与顺铂(DDP)联合化疗治疗晚期胃肠道癌的临床疗效及毒副反应。方法:38例中胃癌18例,大肠癌20例。CF200mg/d,静滴2h,5Fu750mg/d,于CF滴完后立即静滴,维持8h,连用5d;DDP40mg/d静滴,连用3d。28d为1周期。结果:完全缓解7.9%,部分缓解42.1%,稳定42.1%,进展7.9%。总有效率(完全缓解+总分缓解)50.0%,胃癌与大肠癌的有效率分别为55.6%、45.0%,初治与复治有效率为66.7%和35.0%。主要毒副反应为外周静脉炎、口腔黏膜炎、骨髓抑制及恶心呕吐,多为Ⅰ～Ⅱ级。结论:该方案治疗晚期胃肠道癌疗效较好,毒性可耐受,值得临床推广使用。
OBJECTIVE: To evaluate the clinical efficacy and side effects of high-dose combined treatment of 5-fluorouracil (5Fu) and cisplatin (DDP) in the treatment of advanced gastrointestinal cancer. Methods: 38 cases of gastric cancer in 18 cases, 20 cases of colorectal cancer. CF200mg / d, intravenous infusion 2h, 5Fu750mg / d, intravenous infusion immediately after the CF drops, maintained 8h, once every 5d; DDP40mg / d intravenous infusion, even with 3d. 28d for a period. Results: Completely relieved 7.9%, partially relieved 42.1%, stable 42.1%, progress 7.9%. The total effective rate (complete remission + total remission) was 50.0%. The effective rates of gastric cancer and colorectal cancer were 55.6% and 45.0% respectively. The effective rates of primary treatment and retreatment were 66.7% and 35.0%. The main side effects of phlebitis, oral mucositis, bone marrow suppression and nausea and vomiting, mostly Ⅰ ~ Ⅱ grade. Conclusion: The treatment of advanced gastrointestinal cancer has a good curative effect and tolerability. It is worthy of clinical application.