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目的初步评估肝移植治疗肝切除术后复发性肝癌的效果。方法收集四川大学华西医院2001年4月至2008年3月期间23例肝切除术后复发性肝癌接受肝移植病例的资料并进行回顾性分析。结果首次部分肝切除对以后的肝移植手术无明显不利影响,肝移植术后肝功能迅速恢复。17例移植前AFP升高者中13例术后1个月内恢复正常;23例中有5例出现术后并发症,发生率为21.74%;19例完成随访,4例失访,随访率为82.61%。随访截至2008年3月31日,平均随访时间610 d。5例于随访期内发现肝癌复发,复发率为26.32%(5/19);6例于随访期内死亡,生存率为68.42%(13/19),最长存活已达3年2个月。结论对肝切除术后复发性肝癌,肝移植不失为一种较好的治疗方法。
Objective To evaluate the effect of liver transplantation on recurrent liver cancer after hepatectomy. Methods The data of 23 cases of recurrent liver cancer after liver resection received liver transplantation from April 2001 to March 2008 in West China Hospital of Sichuan University were collected and analyzed retrospectively. Results The first partial hepatectomy had no significant adverse effect on the subsequent liver transplantation. Liver function recovered quickly after liver transplantation. Thirteen of the 17 pre-transplant AFP patients returned to normal within 1 month after surgery; 5 of 23 patients developed postoperative complications with a rate of 21.74%; 19 were followed up and 4 were lost to follow-up 82.61%. Follow-up As of March 31, 2008, the average follow-up period was 610 days. The recurrence rate was 26.32% (5/19) in 5 cases. During the follow-up period, 6 cases died. The survival rate was 68.42% (13/19), and the longest survival rate was 3 years and 2 months . Conclusion It is a good treatment for recurrent liver cancer and liver transplantation after liver resection.