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利用小鼠D-半乳糖衰老模型,通过Morris水迷宫(MWM)等动物行为实验和小鼠皮层与海马组织还原型谷胱甘肽和羟自由基含量测定等生化指标实验,对槲皮素延缓脑衰老作用和机制进行了研究.实验结果表明,槲皮素能提高D-半乳糖衰老模型小鼠的空间搜索学习和记忆能力,这些作用与槲皮素改善衰老小鼠皮层和海马的功能、抑制氧化应激反应有关,与增加还原型谷胱甘肽含量以减少羟自由基含量有关.为充分利用槲皮素作为一种天然的抗衰老药物奠定了良好的实验基础.
Using mouse D-galactose aging model, animal behavior tests such as Morris water maze (MWM) and biochemical indicators such as determination of reduced glutathione and hydroxyl radicals in mouse cortex and hippocampus, delayed quercetin Brain aging effects and mechanisms have been studied. Experimental results show that quercetin can improve the spatial search learning and memory ability of D-galactose aging model mice. These effects and quercetin improve the function of cortex and hippocampus in aging mice. The inhibition of oxidative stress is related to the increase of reduced glutathione content to reduce the content of hydroxyl radicals. It has laid a good experimental basis for making full use of quercetin as a natural anti-aging drug.