论文部分内容阅读
目的:探讨血清可溶性尿激酶型纤溶酶原激活物受体(soluble urokinase-type plasminogen activatorreceptor,suPAR)在多发性骨髓瘤(MM)患者血清中的表达、该数值与疾病预后相关因素(分期、年龄、髓外浸润、染色体异常、肾功能、C-反应蛋白、β2-MG等)的关系及其在预测疾病预后方面的临床意义。方法:采用酶联免疫吸附的方法检测40例MM患者和30例正常对照血清suPAR表达水平。结果:①无效组与缓解组、进步组血清suPAR表达比较差异有统计学意义(P<0.05);②生存期<2年组血清suPAR表达高于生存期>2年组(P<0.01);③除血红蛋白数值高低与suPAR数值无相关性外,分期、肾功能异常、C反应蛋白、β2微球蛋白、髓外浸润各组血清suPAR值均差异有统计学意义(均P<0.05);④应用logistic回归对诸因素与患者生存期间的关系进行分析,表明疾病分期、suPAR表达水平高是导致患者生存期不足2年的独立因素。结论:suPAR水平增高与MM疾病进展、生存期缩短、早期出现髓外浸润等因素有关,提示预后不良。
Objective: To investigate the expression of serum soluble urokinase-type plasminogen activator receptor (suPAR) in the serum of patients with multiple myeloma (MM). The correlation between the value and the prognostic factors (staging, Age, extramedullary infiltration, chromosomal abnormalities, renal function, C-reactive protein, β2-MG, etc.) and their clinical significance in predicting disease prognosis. Methods: The serum level of suPAR was detected by enzyme-linked immunosorbent assay in 40 MM patients and 30 normal controls. Results: ① The expression of suPAR in inactive group and remission group was significantly different from that in advanced group (P <0.05); ② The level of suPAR expression in survival group was lower than that in survival group> 2 years (P <0.01); ③In addition to hemoglobin level and suPAR values have no correlation, staging, renal dysfunction, C reactive protein, β2 microglobulin, extramedullary infiltration of serum suPAR values were significantly different (P <0.05); ④ Logistic regression analysis of the relationship between the factors and patient’s survival showed that the stage of disease and the high level of suPAR expression were the independent factors that led to the survival of patients less than 2 years. CONCLUSIONS: The increased suPAR levels are associated with the progression of MM disease, shortened survival and early extramedullary infiltration, suggesting a poor prognosis.