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目的 研究高暴露于铅的条件下 ,δ 氨基乙酰丙酸脱水酶 (ALAD)和维生素D受体(VDR)基因多态性对儿童铅中毒易感性的影响。方法 分析了 4 6 9名严重铅暴露儿童ALAD和VDR基因多态性、血铅、锌原卟啉 (ZPP)、头围、身高和体重等指标。结果 具有ALAD2等位基因个体 ,血中ZPP水平高于不含该等位基因的个体 (P =0 .0 17) ;携带VDRB等位基因个体的头围大于仅携带b等位基因者 (5 1.19cm和 5 0 .75cm) (P =0 .0 2 8)。结论 在高水平铅暴露儿童中 ,ALAD多态性可影响铅的血液毒性效应 ,VDR基因的遗传变异改变铅对儿童颅骨发育的作用程度。ALAD和VDR基因多态性是影响严重铅暴露条件下儿童铅中毒易感性的分子遗传学因素。
Objective To investigate the effect of ALAD and VDR gene polymorphisms on susceptibility to lead exposure in children exposed to lead. Methods The ALAD and VDR gene polymorphisms, blood lead, zinc protoporphyrin (ZPP), head circumference, height and weight of 469 children with severe lead exposure were analyzed. Results Individuals with ALAD2 allele had higher serum ZPP levels than those without this allele (P = 0.017). The head circumference of individuals with VDRB alleles was greater than those with only b allele 1.19 cm and 5.0 0.75 cm) (P = 0.028). Conclusion ALAD polymorphism can affect the hematotoxicity of lead in children exposed to high levels of lead. The genetic variation of VDR gene changes the effect of lead on the development of children’s skull. ALAD and VDR gene polymorphisms are molecular genetic factors that influence the susceptibility of childhood lead poisoning under severe lead exposure.