目的通过观察,了解新生儿窒息的临床特点及情况。方法抽取50例窒息新生儿(窒息组)的静脉血用全自动生化分析仪对心肌酶谱的变化进行检测,按照窒息检测结果分为重度窒息组(1 min Apgar评分≤3分)23例与轻度窒息组(1 min Apgar评分4~7分)27例。对照组患儿选取32例足月、健康新生儿。回顾性分析50例窒息新生儿的临床症状、体征、诊疗等相关指标,以了解新生儿窒息后心肌酶活性变化情况。结果本研究中,治疗前轻度、重度窒息组新生儿血清肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)水平较对照组更高(P<0.05);窒息组患儿经治疗1周后,采取速率法进行检测,发现谷草转氨酶(AST)、乳酸脱氢酶(LDH)、α羟丁酸脱氢酶(α-HBDH)、CK及CK-MB活性均维持较高水平,但与治疗前相比明显下降(P<0.01)。结论对窒息新生儿实施血清心肌酶谱水平检测,可准确反映出心肌损伤情况,为相关治疗提供有效参考,对于患儿早期康复具有重要的意义。通过给予针对性治疗方案,可降低并发症与后遗症发生率。 Objective To observe the clinical features and conditions of neonatal asphyxia. Methods Fifty asphyxial newborns (asphyxia group) were enrolled in this study. Changes of myocardial enzymes were detected by automatic biochemical analyzer. According to the results of asphyxia, 23 patients with severe asphyxia group (1 min Apgar score ≤3) Mild asphyxia group (1 min Apgar score 4 to 7 points) in 27 cases. Control group of children selected 32 cases of full-term, healthy newborn. Retrospective analysis of 50 cases of asphyxia newborns clinical symptoms, signs, diagnosis and treatment and other related indicators to understand neonatal asphyxia myocardial enzyme changes. Results In the present study, serum creatine kinase (CK) and creatine kinase MB (CK-MB) in neonates with mild and severe asphyxia group were significantly higher than those in control group (P <0.05) After 1 week of treatment, the rate method was used to detect the activity of aspartate aminotransferase (AST), lactate dehydrogenase (LDH), α-hydroxybutyrate dehydrogenase (α-HBDH), CK and CK-MB Level, but significantly decreased compared with before treatment (P <0.01). Conclusion Asphyxia neonatal serum myocardial enzyme level detection can accurately reflect the situation of myocardial injury, provide an effective reference for the treatment, for children with early rehabilitation is of great significance. By giving targeted treatment programs, complications and sequelae can be reduced.