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目的:分析阿托伐他汀不良反应的发生特点和临床表现,为临床合理应用提供参考。方法:检索和分析中国知网中国医院知识总库(CHKD)期刊全文数据库中2001~2014年阿托伐他汀不良反应。对患者性别、年龄、用药剂量、ADR发生时间、原发疾病及不良反应表现等进行统计分析。结果:共检索出47篇文献,48例。其中51~60岁患者不良反应发生较多;每日用药20 mg不良反应发生较多;不良反应累及器官以骨骼肌肉系统为主。结论:在临床应用过程中,应注意阿托伐他汀的不良反应,确保患者用药安全。
Objective: To analyze the characteristics and clinical manifestations of atorvastatin adverse reactions and provide references for clinical rational application. Methods: To search and analyze the adverse reactions of atorvastatin from 2001 to 2014 in the Chinese National Knowledge Infrastructure (CHKD) Journal Full - text Database. The gender, age, dosage, ADR occurrence time, primary diseases and adverse reactions were analyzed statistically. Results: A total of 47 articles and 48 cases were retrieved. Among them, 51 to 60 years old patients had more adverse reactions; 20 mg daily medication adverse reactions occurred more; adverse reactions involving organs dominated skeletal muscle system. Conclusion: In the course of clinical application, we should pay attention to the adverse reactions of atorvastatin to ensure the safety of patients.