用心脏血流动力学方法，超声微测距及全细胞膜片钳制等多种技术，首次较全面系统地证明了中药白花前胡（ＢＱ）及其有效成分甲素（Ｐｄ－Ｉａ）的抗心律失常及化心肌缺血作用。其中ｔｖＰｄ－Ｉａ１～３ｍｇ／ｋｇ增加麻醉犬冠脉流量，减少主动脉血压、＋ＬＶｄＰ／ｄｔｍａｘ、率压积及全身血管阻力，其作用与钙拮抗剂地尔硫卓类似。ｉｖ输入Ｐｄ－Ｉａ０．１５ｍｇ／ｋｇ／ｍｉｎ３０ｍｉｎ，在不影响心率、血压及心肌收缩功能等情况下；迅速改善经１５ｍｉｎ闭塞左前降枝伴３ｈ再灌注的麻醉犬心肌收缩功能不良，再灌后５ｍｉｎ即使心肌节段收缩率恢复到用药前的４１±５１％（Ｐ＜０．０５，ｎ＝８）。Ｐｄ－Ｉａ剂量依赖性地减少钙电流峰值，是一钙内流阻断剂。经１５例住院患者２４小时动态心电图初步观察，ＢＱ口服液对冠心病并发和原因不明性室性心律失常有满意疗效。 Using cardiac hemodynamics, ultrasonic micro-distance measurement and whole-cell patch clamp techniques, the anti-cardiac rhythm of Chinese herbal medicine BQ and its active ingredient A (Pd-Ia) was demonstrated systematically for the first time. Abnormal and myocardial ischemia. Among them, tvPd-Ia1 ~ 3mg/kg increased coronary flow in anesthetized dogs, reduced aortic blood pressure, +LVdP/dtmax, rate pressure product and systemic vascular resistance, and its effect was similar to the calcium antagonist diltiazem. Iv Enter Pd-Ia 0.15mg/kg/min for 30min without affecting heart rate, blood pressure and myocardial contractile function; Rapidly improve myocardial contractile dysfunction after 15min occlusion of left anterior descending artery with 3h reperfusion, 5 min after reperfusion Even myocardial segmental contraction rate returned to 41±51% before administration (P<0.05, n=8). Pd-Ia dose-dependently reduces calcium current peaks and is a calcium influx blocker. According to the preliminary observation of 24-hour Holter in 15 inpatients, BQ oral solution has satisfactory effects on the occurrence of coronary artery disease and unexplained ventricular arrhythmia.