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目的:分析国外植物药协同抗生素的研究应用现状,为国内植物药与化学药相互作用研究提供参考。方法:以Pubmed,Chemical Abstract和BMJ医学数据库为检索对象,对相关文献进行筛选、分类与归纳。结果:1996至今,3个数据库中关于植物药协同抗生素治疗感染性疾病的文献共27篇,研究重点主要集中在中药对抗菌素的协同增效以及中药逆转细菌耐药作用机制的单靶点研究,研究水平主要停留在试管内试验及动物试验阶段。结论:与国内植物药与抗生素类在临床的广泛应用不同,国外植物药协同抗生素治疗感染性疾病的研究结果可靠性高,但多靶点研究较少,所给出的循证医学证据级别较低,离临床应用尚有较大的距离。
OBJECTIVE: To analyze the current situation of the research and application of synergistic antibiotics in botanicals in foreign countries and provide reference for the research on the interaction between botanical drugs and chemical drugs in China. Methods: PubMed, Chemical Abstract and BMJ database were used as the research objects to screen, classify and summarize the related literatures. Results: From 1996 to now, there are 27 articles on synergistic antibiotic treatment of infectious diseases in three databases. The research focuses mainly on the synergistic effects of traditional Chinese medicine on antibiotics and the single target study on the mechanism of traditional Chinese medicine reversing bacterial resistance. The research mainly stays in the test tube and animal experiment stage. Conclusion: Different from the broad application of domestic herbal medicines and antibiotics in clinical practice, the research results of collaborative antibiotics with foreign botanicals in the treatment of infectious diseases are highly reliable, but their research on multiple targets is relatively rare. The evidence-based medical evidences provided Low, there is a greater distance from the clinical application.