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目的探讨沙丁胺醇和沐舒坦对老年COPD急性发作期患者免疫干预疗效。方法应用沙丁胺醇和沐舒坦联合治疗老年COPD急性发作期患者58例作为观察组,60例常规治疗组作为对照组。观察治疗前后两组效果以及应用流氏细胞仪检测CD3、CD4百分率及CD4/CD8比值以及采用双抗体夹心ABC-ELISA法IL-2的变化。结果沙丁胺醇和沐舒坦对老年COPD急性发作期患者治疗后疗效(93.1%)显著高于对照组(73.3%)。差异显著,有统计学意义(P<0.05),反映细胞免疫功能的IL-2水平、CD3、CD4百分率及CD4/CD8比值,治疗后研究组明显高于对照组,差异有统计学意义(P<0.05)。结论沙丁胺醇和沐舒坦对可通过影响免疫功能机制治疗老年COPD急性发作期患者,具有较好的疗效。
Objective To investigate the effect of salbutamol and ambroxol on immune intervention in elderly patients with acute exacerbation of COPD. Methods Salbutamol and ambroxol combined treatment of elderly patients with acute exacerbation of COPD in 58 cases as the observation group, 60 cases of conventional treatment group as a control group. The effect of both groups before and after treatment and the ratio of CD3, CD4 and CD4 / CD8 were detected by flow cytometry and the change of IL-2 by double antibody sandwich ABC-ELISA. Results The efficacy of salbutamol and ambroxol in the treatment of elderly patients with acute exacerbation of COPD was significantly higher (93.1%) than that of the control group (73.3%). (P <0.05), the level of IL-2, the percentage of CD3, CD4 and the ratio of CD4 / CD8, which reflect the cellular immune function, were significantly higher in the study group than in the control group, with significant difference (P <0.05). Conclusions Salbutamol and ambroxol have better therapeutic effects on patients with acute COPD exacerbation by influencing immune function mechanism.