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研究一氧化氮 (NO)、内皮素 (ET)和抗利尿激素 (ADH)在肝硬化中的变化与门脉高压的关系。方法 :用比色法测定 5 8例肝硬化患者血浆的 NO;用 EL ISA法分别测定 5 8例肝硬化患者血浆的 ET和 ADH。结果 :NO、ET和ADH在肝硬化时均显著升高 ,肝功能越差 ,升高越明显 ,有腹水患者较无腹水患者显著升高 ;NO、ET与门、脾静脉宽度呈显著正相关 (r=0 .6 1、0 .5 8,P<0 .0 5 ) ;ADH与 2 4小时尿量及尿钠排出量呈显著负相关 (r=- 0 .6 2、- 0 .5 6 ,P<0 .0 5 )。结论 :NO和 ET参与了门脉高压的形成 ,ADH主要与肝硬化患者 2 4小时尿量及尿钠排出量下降有关。
To study the relationship between changes of nitric oxide (NO), endothelin (ET) and antidiuretic hormone (ADH) in cirrhosis and portal hypertension. Methods: Plasma NO was measured by colorimetric assay in 58 patients with cirrhosis. Plasma ET and ADH were measured in 58 patients with cirrhosis by ELISA. Results: NO, ET and ADH were significantly increased in cirrhosis, liver function worse, the more obvious increase, patients with ascites were significantly higher than those without ascites; NO, ET and portal vein and splenic vein width was positively correlated (r = 0. 6 1.05.8, P <0.05). There was a significant negative correlation between ADH and 24-hour urine output and urinary sodium excretion (r = -0.62, -0.5 6, P <0. 05). Conclusions: NO and ET are involved in the formation of portal hypertension. ADH mainly correlates with 24-hour urine output and decreased urinary sodium excretion in cirrhotic patients.