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目的:探讨卵巢上皮性癌组织中结肠癌转移相关基因1(metastasis-associated in colon cancer-1,MACC1)的表达及其临床意义。方法:应用RT-PCR和免疫组织化学法检测卵巢上皮性癌组织、卵巢上皮性良性肿瘤组织及正常卵巢组织中MACC1 mRNA及蛋白的表达,分析MACC1蛋白的表达与卵巢上皮性癌患者临床病理特征之间的关系。结果:卵巢上皮性癌组织中MACC1 mRNA和蛋白的表达水平均明显高于卵巢上皮性良性肿瘤组织和正常卵巢组织(P<0.05)。卵巢上皮性良性肿瘤组织与正常卵巢组织之间MACC1 mRNA和蛋白的表达水平无明显差异(P>0.05)。MACC1蛋白的阳性表达率与卵巢上皮性癌患者的临床分期、组织分化程度和淋巴结转移等因素相关(P<0.05)。结论:MACC1蛋白表达与卵巢上皮性癌患者的临床分期、组织分化程度和淋巴结转移相关。MACC1可能参与了卵巢上皮性癌的发生和发展。
Objective: To investigate the expression of metastasis-associated in colon cancer-1 (MACC1) and its clinical significance in epithelial ovarian cancer. Methods: The expression of MACC1 mRNA and protein in ovarian epithelial carcinoma, benign epithelial ovarian tumor and normal ovarian tissue was detected by RT-PCR and immunohistochemistry. The expression of MACC1 protein and the clinicopathological features of epithelial ovarian cancer The relationship between. Results: The expression of MACC1 mRNA and protein in epithelial ovarian cancer was significantly higher than that in benign epithelial ovarian tumor and normal ovarian tissue (P <0.05). There was no significant difference in the expression of MACC1 mRNA and protein between ovarian epithelial benign tumor tissues and normal ovarian tissues (P> 0.05). The positive expression rate of MACC1 protein was correlated with clinical stage, histological grade and lymph node metastasis in patients with epithelial ovarian cancer (P <0.05). Conclusion: The expression of MACC1 protein is correlated with clinical stage, histological differentiation and lymph node metastasis in patients with epithelial ovarian cancer. MACC1 may be involved in the occurrence and development of epithelial ovarian cancer.