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目的：探讨选择性钙通道阻滞剂氟桂嗪（Ｆｌｕｎａｒｉｚｉｎｅ，ＦＮＺ）对缺氧缺血脑损伤（ＨＩＥ）的治疗作用。方法：将９０只新生ＳＤ大鼠随机分成正常对照组、缺氧缺血脑损伤组和ＦＮＺ治疗组。检测各组脑组织病理变化、脑神经细胞内游离钙、氧自由基、超氧化物歧化酶（ＳＯＤ）、丙二醛（ＭＤＡ）、谷胱甘肽过氧化物酶（ＧＳＨ－ＰＸ）、总抗氧化能力（ＴＡＣ）等指标。结果：（１）ＦＮＺ治疗组ＳＯＤ活力、ＧＳＨ－ＰＸ活力、ＴＡＣ高于对照组，ＭＤＡ、细胞内游离钙低于对照组（Ｐ＜０．０１）；（２）ＦＮＺ组脑组织含水量低于对照组（Ｐ＜０．０５）。结论：ＦＮＺ对新生大鼠脑组织具有一定的治疗和保护作用
Objective: To investigate the therapeutic effect of selective calcium channel blocker Flunarizine (FNZ) on hypoxic-ischemic brain damage (HIE). Methods: 90 newborn SD rats were randomly divided into normal control group, hypoxic-ischemic brain injury group and FNZ-treated group. The changes of brain tissue pathological changes, intracellular free calcium, oxygen free radicals, SOD, MDA, GSH-PX, Antioxidant capacity (TAC) and other indicators. Results: (1) SOD activity, GSH-PX activity, TAC in FNZ treatment group were higher than those in control group, MDA and intracellular free calcium were lower than those in control group (P <0.01); (2) In the control group (P <0.05). Conclusion: FNZ has certain therapeutic and protective effects on the brain of neonatal rats