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目的研究肿瘤增殖细胞核抗原(PCNA)、凋亡抑制蛋白(COX-2)在局部晚期非小细胞肺癌(NSCLC)肿瘤组织中的表达与患者预后的相关性。方法 2005年11月至2012年3月60例局部晚期NSCLC患者肿瘤组织采用免疫组化方法检测PCNA和COX-2蛋白的表达,分析其与患者预后的关系。结果 60例NSCLC组织中PCNA和COX-2的阳性表达率分别为63.3%和60.0%。同步放化疗后,PCNA阳性表达肿瘤客观缓解率高(P=0.046),COX-2阳性表达肿瘤客观缓解率低(P=0.027);COX-2阳性表达与患者无进展生存期和总生存期呈显著负相关(P=0.001)。结论 PCNA、COX-2蛋白表达对局部晚期非小细胞肺癌患者同步放化疗预后有一定预测意义。
Objective To study the correlation between the expression of proliferating cell nuclear antigen (PCNA) and apoptosis-inhibitory protein (COX-2) in locally advanced non-small cell lung cancer (NSCLC) and their prognosis. Methods From November 2005 to March 2012, 60 cases of locally advanced NSCLC patients were examined for the expression of PCNA and COX-2 protein by immunohistochemistry. The relationship between the expression of COX-2 and the prognosis was analyzed. Results The positive rates of PCNA and COX-2 in 60 NSCLC tissues were 63.3% and 60.0% respectively. After concurrent chemoradiotherapy, the objective response rate of PCNA-positive tumors was high (P = 0.046), and the objective response rate of COX-2 positive tumors was lower (P = 0.027). The positive expression of COX-2 correlated with the progression-free survival and overall survival There was a significant negative correlation (P = 0.001). Conclusions The expression of PCNA and COX-2 protein has some predictive value for the prognosis of patients with locally advanced non-small cell lung cancer.