p53是目前发现的与人类肿瘤发病相关性最大的抑癌基因之一。野生型p53参与DNA损伤修复、细胞周期调控、细胞凋亡及抑制血管生成等。p53基因的突变会使上述功能丧失,从而导致肿瘤的形成。随着分子生物学技术的发展,对肿瘤抑制基因p53的研究越来越深入。本文综合近年来国内外的研究进展,就p53与肿瘤形成的关系及其在肿瘤治疗中的应用等作一综述。 p53 is one of the most commonly found tumor suppressor genes found in human cancers. Wild-type p53 is involved in DNA damage repair, cell cycle regulation, apoptosis and inhibition of angiogenesis. Mutations in the p53 gene result in the loss of these functions, leading to tumor formation. With the development of molecular biology technology, the research on tumor suppressor gene p53 is more and more in-depth. This review summarizes the research progress at home and abroad in recent years and summarizes the relationship between p53 and tumor formation and its application in cancer therapy.