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目的 检测多发性脑梗死性痴呆 (MID)及脑梗死 (CI)患者血清载脂蛋白E(ApoE)含量 ,探讨ApoE测定的临床意义。 方法 选取 2 0例MID患者、2 4例CI患者及 2 4例正常对照者 ,分别运用单克隆抗体ELISA法测定血清ApoE含量 ,同时测定血清TC、TG、HDL C、LDL C、ApoA和ApoB含量 ,并进行相关分析。结果 与对照组比较 ,MID和CI患者血清ApoE、ApoB及LDL C含量显著升高 (P <0 .0 5 ) ,HDL C和ApoA含量显著降低 (P <0 .0 1) ,TC及TG含量升高 ,但无统计学意义 (P >0 .0 5 )。结论 MID和CI患者均有脂代谢异常 ,血清ApoE可作为检测其脂代谢异常的重要指标
Objective To detect serum apolipoprotein E (ApoE) levels in patients with multiple cerebral infarction dementia (MID) and cerebral infarction (CI) and to investigate the clinical significance of ApoE assay. Methods Twenty cases of MID, 24 cases of CI and 24 normal controls were enrolled in this study. Serum ApoE levels were measured by ELISA and serum levels of TC, TG, HDL C, LDL C, ApoA and ApoB , And make relevant analysis. Results Compared with the control group, the levels of serum ApoE, ApoB and LDL C in patients with MID and CI were significantly increased (P <0.05), the levels of HDL C and ApoA were significantly decreased (P <0.01), the levels of TC and TG But not statistically significant (P> 0.05). Conclusions Both MID and CI patients have abnormal lipid metabolism. Serum ApoE can be used as an important index to detect abnormal lipid metabolism