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模拟临床灌洗方法对染尘家兔进行大容量肺灌洗，并观察灌洗前后肺泡液中细胞及生化成分变化，为灌洗术的应用性评价提供科学依据。结果显示：灌洗后染尘动物肺泡液中除总磷脂，二棕榈酰卵磷脂（ＤＰＰＣ）外，细胞总数、蛋白质含量、乳酸脱氢酶（ＬＤＨ）、碱性磷酸酶（ＡＫＰ）活性均明显低于同期染尘未灌洗组，差异有显著性，此外还可洗出一定量的ＳｉＯ２粉尘，首次灌洗较第二次灌洗为多。提示：灌洗对矽肺发生发展有一定延缓作用，早期灌洗效果较好。
To simulate the clinical lavage method, large-volume lung lavage was performed on infected rabbits and the change of cell and biochemical composition in alveolar fluid before and after lavage were observed, which provided a scientific basis for the application evaluation of lavage. The results showed that the total cell number, protein content, lactate dehydrogenase (LDH) and alkaline phosphatase (AKP) activity in the alveolar fluid were significantly higher than those in the control group Less than the same period of non-lavage dust, the difference was significant, in addition to wash out a certain amount of SiO2 dust, the first lavage than the second lavage for more. Tip: lavage on the development of silicosis have some delay, early lavage better.