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目的探讨茶碱对慢性阻塞性肺疾病稳定期诱导痰白细胞介素-8及肺功能的影响。方法将40例稳定期COPD患者随机分为试验组和对照组,试验组给予茶碱口服,对照组给予安慰剂口服,共8周,观察治疗前后诱导痰白细胞介素8(IL-8)及肺功能的变化。结果试验组患者治疗8周后诱导痰IL-8浓度较治疗前显著降低(P<0.05),肺功能显著改善(P<0.05),而对照组诱导痰IL-8浓度及肺功能治疗前后差异无统计学意义。结论茶碱可减轻COPD患者气道炎症,改善COPD稳定期肺功能。
Objective To investigate the effect of theophylline on sputum interleukin-8 and lung function induced by stable phase of chronic obstructive pulmonary disease. Methods Forty patients with stable COPD were randomly divided into test group and control group. Theophylline was given orally in the test group and the placebo in the control group for 8 weeks. The levels of interleukin 8 (IL-8) Changes in lung function. Results After 8 weeks of treatment, the concentration of IL-8 in induced sputum in the experimental group was significantly lower than that before treatment (P <0.05) and the lung function was significantly improved (P <0.05), while the IL-8 concentration in the control group was significantly lower than that before treatment No statistical significance. Conclusion Theophylline can relieve airway inflammation in COPD patients and improve pulmonary function in stable COPD patients.