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目的:研究环氧化酶-2(COX-2)和血管内皮生长因子(VEGF-C)在鼻咽癌组织中的表达及其临床意义。方法:采用逆转录-聚合酶链法(RT-PCR)检测32例鼻咽癌和11例癌旁鼻咽正常组织标本中COX-2mRNA与VEGF-C-mRNA的表达。结果:COX-2 mRNA与VEGF-CmRNA在鼻咽癌中的表达分别为68.7%和71.9%,显著高于癌旁鼻咽正常组织(P<0.01,P<0.005);在有淋巴结转移患者中COX-2 mRNA与VEGF-C-mRNA阳性表达均明显高于无淋巴结转移患者(P<0.05,P<0.01)。结论:COX-2与VEGF-C基因在鼻咽癌中组织的发生、发展、转移中发挥重要作用。
Objective: To study the expression of cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF-C) in nasopharyngeal carcinoma and its clinical significance. Methods: The expressions of COX-2 mRNA and VEGF-C mRNA in 32 cases of nasopharyngeal carcinoma and 11 cases of adjacent normal tissues were detected by RT-PCR. Results: The expressions of COX-2 mRNA and VEGF-C mRNA in nasopharyngeal carcinoma were 68.7% and 71.9%, respectively, which were significantly higher than those in the adjacent normal tissues (P <0.01, P <0.005). In patients with lymph node metastasis The positive expressions of COX-2 mRNA and VEGF-C mRNA were significantly higher than those without lymph node metastasis (P <0.05, P <0.01). Conclusion: COX-2 and VEGF-C genes play an important role in the occurrence, development and metastasis of nasopharyngeal carcinoma.