论文部分内容阅读
目的:探讨肝衰竭患者应用血浆置换术的临床效果。方法:将90例患者分为观察组和对照组各45例。对照组采取内科综合治疗方法,观察组在对照组的基础上进行血浆置换术。观察组中有早期肝衰竭患者23例,中晚期肝衰竭患者22例。比较患者治疗前后临床症状、肝功能和凝血酶原活动度等指标,判断临床效果,观察治疗中不良反应。结果:血浆置换术后,患者自觉症状均有改善,血清转氨酶及血清胆红素明显降低,凝血酶原活动度明显提高,白蛋白水平增加,总生存率88.9%,与对照组55.6%相比,均具有统计学意义(P<0.05)。治疗中有少数患者发生不良反应,经过对症治疗均好转。观察组早期肝衰竭患者生存率为91.3%,中晚期肝衰竭患者生存率为68.2%,差异有统计学意义(P<0.05)。结论:血浆置换术对于治疗肝衰竭效果明显,对早期肝衰竭的治疗效果明显优于中晚期肝衰竭,安全性较好。
Objective: To investigate the clinical effect of plasma exchange in patients with liver failure. Methods: 90 patients were divided into observation group and control group, 45 cases each. The control group to take the comprehensive medical treatment, the observation group in the control group based on plasmapheresis. There were 23 patients with early liver failure in the observation group and 22 patients with advanced liver failure. Before and after treatment of patients with clinical symptoms, liver function and prothrombin activity and other indicators to determine the clinical effect, observation of adverse reactions during treatment. Results: After the plasmapheresis, the symptoms of the patients were improved, the levels of serum aminotransferase and serum bilirubin were significantly decreased, the prothrombin activity was significantly increased, the albumin level was increased, the overall survival rate was 88.9%, compared with 55.6% of the control group , All with statistical significance (P <0.05). A small number of patients treated adverse reactions, after symptomatic treatment were improved. The survival rate of patients with early liver failure in the observation group was 91.3%, and the survival rate of patients with advanced liver failure was 68.2%. The difference was statistically significant (P <0.05). Conclusion: Plasmapheresis is effective in treating liver failure, and it is superior to advanced liver failure in treatment of early liver failure.