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目的 观察毛细支气管炎患儿血清嗜酸细胞阳离子蛋白 (ECP)、总IgE(T IgE)、外周血嗜酸细胞 (EOS)的变化。方法 应用荧光酶联免疫法测定 2 5例毛细支气管炎 ,2 6例哮喘 ,2 0例肺炎和 15例正常儿童血清ECP、T IgE水平 ,并作外周血EOS计数。结果 毛细支气管炎患儿血清ECP、T IgE水平及EOS计数 (分别为 3 91± 2 17μg/L ,174 6 5± 3 5 0ku/L和 75 88± 1 96× 10 6/L)介于哮喘组 (分别为 6 6 2± 2 12 μg/L ,781 6 6± 2 2 6ku/L和 112 86± 2 31× 10 6/L)与肺炎组(分别为 2 5 9± 1 41μg/L ,10 6 48± 3 6 7ku/L和 6 2 71± 1 34× 10 6/L)和正常对照组 (分别为 2 5 8± 1 36 μg/L ,10 6 6 8± 3 2 7ku/L和 6 1 84± 1 6 4× 10 6/L)之间 ,有非常显著性差异 (P均 <0 0 0 1)。结论 毛细支气管炎和哮喘可能存在着相同或相似的免疫学发病机制
Objective To observe the changes of serum eosinophil cationic protein (ECP), total IgE (T IgE) and peripheral blood eosinophil (EOS) in children with bronchiolitis. Methods Serum ECP and T IgE in 25 cases of bronchiolitis, 26 cases of asthma, 20 cases of pneumonia and 15 cases of normal children were detected by fluorescence enzyme-linked immunosorbent assay. Results Serum levels of ECP, T IgE and counts of EOS in children with bronchiolitis (3 91 ± 2 17 μg / L, 174 6 5 ± 350 5 ku / L, and 75 88 ± 1 96 × 10 6 / L, respectively) (6 6 2 ± 2 12 μg / L, 781 6 6 ± 226 kku / L and 112 86 ± 2 31 × 10 6 / L, respectively) and pneumonia group (259 ± 1 41 μg / L, 10 6 48 ± 3 6 7 ku / L and 6 2 71 ± 1 34 × 10 6 / L) and control group (25 8 ± 1 36 μg / L, 106 6 ± 3 27 ku / L and 6 1 84 ± 1 6 4 × 10 6 / L), there was a significant difference (all P <0 0 0 1). Conclusion The same or similar immunological pathogenesis may exist in bronchiolitis and asthma