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草乌与犀角配伍属于中药的“十九畏”内容之一。实验用水牛角代替犀角与草乌配伍，在生理条件及免疫功能低下的条件下就二者配伍前后进行镇痛、抗炎、免疫、血液等药理指标的观察研究，结果表明：对镇痛、抗炎、白细胞、胸腺、凝血时间等指标，单用时有作用，合用后作用不如单味；对脾指数，单用合用均无影响；水牛角有一定的降温作用，与草乌合用后对体温均无影响。提示二药配伍可属中药七情中的“相恶”范畴。
The combination of Aconitum and Rhinoceros is one of the nineteen fears of traditional Chinese medicine. The experimental water ox horn replaces the rhinoceros and the combination of Aconitum nigra and the pharmacological indexes such as analgesia, anti-inflammation, immunity, and blood before and after compatibility in physiological conditions and low immune function. The results show that: Inflammation, leukocyte, thymus, coagulation time and other indicators, when used alone, have a role, after combined use is not as good as single taste; for the spleen index, single use has no effect; buffalo horn has a certain cooling effect, and the combination of Kusao and the body temperature are no effect. It is suggested that the compatibility of the two drugs may belong to the category of “evil” in the seven situations of traditional Chinese medicine.