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目的探讨对溃疡性结肠炎患者采用美沙拉嗪联合柳氮磺吡啶治疗的临床疗效。方法 80例溃疡性结肠炎患者,依据治疗药物不同分为对照组和观察组,各40例。对照组应用单纯柳氮磺吡啶治疗,观察组在对照组基础上加用美沙拉嗪治疗,比较两组临床疗效。结果对照组总有效率77.5%低于观察组的95.0%,对照组不良反应发生率17.5%高于观察组的2.5%,对照组治疗后组织学积分(1.27±0.34)分高于观察组的(0.79±0.15)分,对比差异均具有统计学意义(P<0.05)。结论美沙拉嗪与柳氮磺吡啶治疗溃疡性结肠炎临床疗效优良,安全性高,值得推广。
Objective To investigate the clinical efficacy of mesalazine combined with sulfasalazine in patients with ulcerative colitis. Methods Eighty patients with ulcerative colitis were divided into control group and observation group according to different therapeutic drugs, 40 cases in each. The control group was treated with sulfasalazine alone. The observation group was treated with mesalazine on the basis of the control group, and the clinical efficacy was compared between the two groups. Results The total effective rate in the control group was 77.5% lower than 95.0% in the observation group, 17.5% in the control group was higher than 2.5% in the observation group, and 1.27 ± 0.34 in the control group was higher than that in the observation group (0.79 ± 0.15) points, the difference was statistically significant (P <0.05). Conclusion Mesalazine and sulfasalazine are effective and safe for the treatment of ulcerative colitis, and should be popularized.